In a groundbreaking study, researchers at Tel Aviv University, leading a large-scale international team of scientists, say they have identified – and neutralized – an RNA molecule that can stop the nerve cell damage that causes paralysis in patients with amyotrophic lateral sclerosis, ALS.
Axar.az, citing Times of Israel, informs that now they hope they can use the discovery to help patients with the fatal illness.
“When we added a specific RNA molecule to human cells and animal models for ALS, the nerve cells stopped degenerating and even regenerated,” said Prof. Eran Perlson from the Gray Faculty of Medical & Health Sciences and the Sagol School of Neuroscience at Tel Aviv University.
ALS, sometimes called Lou Gehrig’s disease, is a fatal neurodegenerative condition that affects motor neurons — the nerve cells that control muscle movement. Over time, the disease causes gradual paralysis of all muscles in the body. Patients typically lose their ability to walk, speak, swallow, and breathe, often becoming completely paralyzed while their cognitive skills remain intact.
“Most patients die within three to five years of diagnosis, due to paralysis of the diaphragm muscles and respiratory failure,” said Perlson.