Researchers in Germany have developed a new toothpaste designed to combat periodontitis by selectively blocking harmful bacteria while leaving beneficial oral microbes intact, a breakthrough that could reshape preventive dental care.

Axar.az reports that scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI said the innovation addresses a major weakness in conventional mouthwashes and antiseptic products, which often kill both harmful and helpful bacteria. That can allow disease-causing microbes to return quickly and disrupt the mouth’s natural microbial balance.

The new formula targets pathogens linked to gum disease, particularly Porphyromonas gingivalis, a bacterium associated with inflammation, gum recession and tooth loss. Researchers said chronic periodontitis has also been linked to broader health risks, including cardiovascular disease, diabetes and Alzheimer’s disease.

Instead of destroying bacteria outright, the active compound works by inhibiting the growth of harmful microbes, allowing beneficial bacteria to repopulate the mouth and restore a healthier microbiome, according to lead researcher Stephan Schilling.

The technology has been commercialized by PerioTrap Pharmaceuticals GmbH, a spin-off founded in 2018. The company said the toothpaste also contains fluoride and standard cleaning agents to help prevent tooth decay alongside gum disease.

Researchers said the product underwent development under Good Laboratory Practice standards to ensure safety and quality. Additional products based on the same technology — including a mouthwash, professional dental gel and even pet oral-care items — are now in development.

The launch comes amid growing scientific interest in microbiome-based healthcare, where treatments aim to restore natural bacterial ecosystems rather than eliminate them entirely.